sovietknuckles
1h ago
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sovietknuckles
7h ago
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Elon Musk's politically views do not align with
oursmy SO's friends' and we are embarrassed.
sovietknuckles
12h ago
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Link it, lib
sovietknuckles
2d ago
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sovietknuckles
4d ago
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In short - best $20 I've ever spent.
People pay money to use ChatGPT?
sovietknuckles
4d ago
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wtf I love Mr Beast now
sovietknuckles
6d ago
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kolektiva.social/Kolektiva is an anti-colonial anarchist collective that offers federated social media to anarchist collectives and individuals in the fediverse. It has 3,489 monthly users
sovietknuckles
6d ago
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100%
The thread is brigaded by Destiny watchers, including that user
https://old.reddit.com/r/FriendsofthePod/comments/1g2nbe6/discussion_offline_with_jon_favreau_hasan_piker/?sort=top&limit=500
sovietknuckles
1w ago
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Think about it, Derek
sovietknuckles
1w ago
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my first wife and this one
Divorced dad energy off the charts
sovietknuckles
2w ago
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"A recent poll reveals that more UK residents believe that Hamas, Iran, or Hazbollah are to blame for the conflict than do Israel"
sovietknuckles
2w ago
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What does this mean?
#1 – Denial – Pretending a problem does not exist to provide artificial relief from anxiety.
Citing excess mortality without adjusting for survivorship bias.
I found this article:
- Accelerated deaths and survivorship bias: The excess deaths directly attributed to COVID-19 are most likely not realized in a world without COVID-19. In other words, they are carried forward, or accelerated, from expected deaths in the future. This rate of acceleration largely depends on, firstly, the percentage of excess COVID-19 deaths, which depends on the duration and severity of the pandemic, and, secondly, the mortality risk differential in factors such as age, gender, and socio-economic status. All else being equal, accelerated deaths may bring forth lower than expected mortality rates, or “negative” excess deaths, in the future.
So they're saying that because COVID kills the most vulnerable people first, future excess deaths will be decreased as a result because so many of the vulnerable people are already dead?
sovietknuckles
2w ago
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The bright side to electing ancient presidents is that they don't have as long to be rehabilitated
sovietknuckles
2w ago
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A real leader would have caught the shoes with their face and say "Shoe, coward! You are only going to fit a man"
sovietknuckles
3w ago
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100%
economists
Suddenly it all lines up
sovietknuckles
3w ago
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:::spoiler guys literally only want one thing and it's fucking disgusting
:::
sovietknuckles
3w ago
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100%
Pfizer doesn't make the vaccines, BioNTech does. Pfizer just owns BioNTech, and Pfizer would only advertise the COVID vaccines if they think COVID vaccines are more profitable than the other products that Pfizer sells.
It looks like they think being unvaccinated against COVID is more profitable
sovietknuckles
3w ago
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100%
What's the point of passing the bill if they're not willing to override the veto? They're just letting Gavin Newsom be the spoiler, even though others would step up to spoil if he did not
sovietknuckles
3w ago
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100%
i.e. no one masks anyway, might as well do what appeals to them instead of advocate militantly for what should be done — and that just really bums me out.
I think that's that's the target audience, people who can't or won't mask. My parents won't mask when out of the house unless I'm there watching them, for example, and sometimes not even then. If your job won't let you mask or makes it difficult, nasal sprays can help in that case, too.
For maskers like myself, it's particularly useful in airport security, where they make me take off my mask for identification, and airport terminals and airplanes, where I might want to eat but there's a lot of other people around.
sovietknuckles
3w ago
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100%
plus they couldn't find a mask that works with their glasses
Most KN95s and all N95s I have tried fog my glasses. But ProGear N95s don't, that's the kind that I prefer. Once you put it on, you can press the metal nose band to fit it to your exact nose shape
But I've also read enough anecdotal reports from people who use them and still got sick with covid. Who knows if they were properly applied,
Maybe it's important to get one with a good spray. The Betadine iota carrageenan spray is very good, with respect to diffusion. It also doesn't require shaking or spraying beforehand to get a full spray.
Some Covixyl bottles don't diffuse the spray well, and it's very noticeable
but I doubt these sprays alone will do much if your exposure levels are high.
And if there's enough COVID in the air, you can get COVID in your eyes, not just your nose. Wearing Stoggles helps if someone coughs in your direction, but not if there's just lots of COVID in the air
This mucosal/nasal vaccine is called MPV/S-2P and it is developed by the NIH's National Institute of Allergy and Infectious Diseases (NIAID). From a [2023 study](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543296/): > A single dose of MPV/S-2P was highly immunogenic, and a second dose increased the magnitude and breadth of the mucosal and systemic anti-S antibody responses and increased levels of dimeric anti-S IgA in the airways. Obviously don't dox yourself on Hexbear, but the phase 1 trial sites are: :::spoiler Decatur, Georgia The Hope Clinic of Emory University ::: :::spoiler Mineola, New York, United States NYU Grossman Long Island School of Medicine - Vaccine Center ::: :::spoiler Houston, Texas, United States Baylor College of Medicine ::: so if you live near one of those, maybe you can participate. They want to enroll 60 people, no clue how close they are to that goal To try to enroll, [contact them](https://clinicaltrials.gov/study/NCT06441968?term=NCT06441968&rank=1&tab=table) by phone or email.
The spray is called "Pathogen Capture and Neutralizing Spray" (PCANS) for now > This data suggest PCANS as a promising daily-use prophylactic against respiratory infections. [The study](https://onlinelibrary.wiley.com/doi/10.1002/adma.202406348) is paywalled, and the abstract doesn't list its ingredients beyond > The formulation consists of excipients identified from the FDA's Inactive Ingredient Database and Generally Recognized as Safe list to maximize efficacy for each step in the multi-modal approach. Based on that description, its ingredients might not be very different from Covixyl, though it claims to be much more effective. Edit: Apparently its already for sale, I included some details in [a comment](https://hexbear.net/comment/5436030)
https://xcancel.com/nytopinion/status/1829879853165765055 https://archive.ph/lxKBc https://www.nytimes.com/2024/08/31/opinion/heat-wave-air-conditioning-climate-change.html
Don't bother with opsec, I printed them off in high DPI
[CW: Vox]
https://www.bloomberg.com/news/articles/2024-08-08/microsoft-palantir-team-up-to-sell-ai-to-us-defense-intelligence-agencies
> This month, there are some clinical results for a mucosal next generation Covid vaccine – the 30th mucosal vaccine on my list of mucosal vaccines that have gone into clinical trial. Plus, I’ve added over a dozen preclinical reports to my collection, including more results showing prevention of transmission or durable immunity. And an intranasal vaccine based on an agent called a STING agonist showed strong protection from other coronaviruses, as well as protection against transmission. > > :::spoiler News from US Project NextGen > As well as funding trials of next generation Covid vaccines, Project NextGen is funding research on the correlates of protection from authorized vaccines (studying levels of antibodies etc associated with effective vaccination). To try to ensure a group of participants that is more diverse than is usual for clinical trials based in hospitals and universities, [they announced this month](https://aspr.hhs.gov/newsroom/Pages/Project-Walgreens-23July2024.aspx) a pharmacy-based initiative to broaden access. About 20 Walgreens pharmacies in urban, suburban, and rural areas will be clinical trial sites, and “To recruit study volunteers, Walgreens will provide information on how and where to participate in the study.” > > This decentralized trial will also get technical and other support from the Fred Hutch Cancer Center – and the Center has [also been funded](https://medicalcountermeasures.gov/newsroom/2024/fhcc/) to support some of the next generation vaccine trials. > > In other Project NextGen news, Castlevax – who will be running one of the phase 2b “mini-efficacy” trials for their intranasal vaccine – [announced](https://www.businesswire.com/news/home/20240730713002/en/CastleVax-Inc.-Receives-34-Million-from-BARDA-to-Continue-Advancing-Intranasal-NDV-based-COVID-19-Vaccine-into-Phase-2b-Clinical-Efficacy-Testing) they received additional funding for that trial. > > Finally, last update, [I reported](https://absolutelymaybe.plos.org/2024/06/30/a-mini-surge-of-clinical-trials-and-advances-for-people-with-immunosuppression-nextgen-covid-vax-update-18/#mucosal) that a mucosal vaccine developed by the NIH’s NIAID was entering a phase 1 trial. Soon after, [the NIH announced](https://www.nih.gov/news-events/news-releases/nih-sponsored-trial-nasal-covid-19-vaccine-opens) that recruitment had begun, and that this was the first Project NextGen-funded clinical trial. > ::: > > :::spoiler Mucosal vaccine news > This month, I added a 30th mucosal vaccine that has gone into clinical trial. (I missed this one when it went into [a clinical trial in China last year](https://trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR2300070346).) It’s an intranasal viral vector vaccine called Ad5-S-Omicron BA.1, based on adenovirus 5, and Omicron. The developers [reported some results](https://www.nature.com/articles/s41392-024-01906-0) for 8 people in the phase 1 trial, along with a transmission study in mice. > > The people in the clinical trial had been vaccinated with other vaccines at least 6 months before getting 2 doses of nasal spray. The developers tested their people’s blood and nasal fluids to see if they showed signs of immune response to new Omicron variants. > > Nasal immunoglobulin, they reported, “retained potent neutralization” against all the Covid variants they tested, though serum immunoglobulins did not for all of them. > > The developers then tested the impact on mice of intranasal application of the vaccinated people’s immunoglobulin. There were 4 groups of mice getting different immunoglobulin, and a control group getting immunoglobulin from people who did not have the intranasal vaccine. The mice getting the vaccinated people’s nasal immunoglobulin “showed a significant and comparable reduction in viral load.” > > *More new preclinical results:* > > I’ve added 7 preclinical reports on results for another 5 mucosal vaccines to my collection since the last update, with one reported below in the pancoronavirus vaccine category. The others include: > > * Tokyo Metropolitan Institue of Medical Science and Toko Yakuhin Kogyo Co (Japan): This vaccine is a protein subunit mixed with carboxyvinyl polymer (CVP), [tested](https://www.mdpi.com/2076-393X/12/7/794) intranasally in mice. The developers reported levels of longterm efficacy (at least 15 months). > > * Friedrich Loeffler Institute (Germany) and University of Bern (Switzerland): [This report](https://www.nature.com/articles/s41564-024-01755-1) is for genome-modified live-attenuated vaccines, tested as a single intranasal dose in mice and hamsters. For one of them, unimmunized hamsters put in contact with immunized animals after a Covid challenge test had minimal viral RNA in nasal washings and no signs of the virus in organs. > > * Ohio State University (USA): This group developed several versions of viral vector vaccine based on 3 Covid variants. The viral vectors were measles and mumps components of the MMR vaccine. [The developers reported](https://www.nature.com/articles/s41467-024-49443-2) on testing these intranasally in mice and hamsters. > ::: > > :::spoiler Pancoronavirus vaccine news > Pancoronavirus vaccines aim to provide protection not only from variants of the SARS virus that causes Covid, but also against the next new coronavirus to spread among humans. This month, 3 vaccines have joined this category, all from the US. > > *NanoSTING-SN: A mucosal protein subunit vaccine from the University of Houston and Auravax (USA)* > > NanoSTING is the name for a mucosal adjuvant that is a STING agonist, a class of agents that can stimulate immune activity. (STING stands for stimulator of interferon genes.) Different versions of this vaccine [were tested](https://www.nature.com/articles/s41467-024-50133-2) in mice and hamsters. > > Hamsters got 2 intranasal doses of the SN version, and then had a challenge test with the Delta variant, along with an unvaccinated group. The vaccinated hamsters had reduced viral loads, and by day 6, no virus was detectable. > > The developers did a transmission study using the SN version in hamsters. One group had sham immunization, and a group of 8 hamsters had 2 intranasal doses of SN, 21 days apart. The immunized hamsters were challenged with an Omicron variant on day 35, and a day later, each was co-housed with an unimmunized hamster. > > The vaccine protected the 8 hamsters from getting sick, and only 2 showed a low amount of virus in lung and nasal tissue. No virus was detected in any of the contact hamsters. The experiment was repeated with a single intranasal dose: This also prevented transmission. > > The developers tested blood from mice vaccinated with the SN version and found signs of immune response to a group of other coronaviruses, including the original SARS and MERS, as well as an alphacoronavirus. > > Then, a group of vaccinated and unvaccinated mice were challenged with the original SARS. The unvaccinated mice showed signs of illness, but the vaccinated ones did not, and all survived. > > Finally, the developers vaccinated 3 primates (rhesus macaques) with 2 intranasal doses, 28 days apart. Signs of immune response were consistent with those of the mice. > > This is the fourth preclinical report for this vaccine – all records here. > > *A protein subunit vaccine from Georgia State University (USA)* > > Four versions of this vaccine were tested. One of them, based on the Delta variant, showed signs of protection from all the Covid variants tested. Immunized mice were also protected in challenge experiments with the Delta variant, and the original SARS. > > This is the second preclinical report for this vaccine – the first is here. > > *A protein subunit vaccine from Baylor College of Medicine (USA)* > > This vaccine aims to provide protection from betacoronaviruses, and is based on components of the original SARS, MERS, and an Omicron variant. The vaccine was [tested in mice](https://www.nature.com/articles/s41541-024-00924-x). The mice showed signs of response to all of those viruses, as well as betacoronaviruses that are currently only infecting bats. > :::
> The final update of the NIH COVID-19 Treatment Guidelines was on February 29, 2024. PDFs of the Guidelines can be downloaded until August 16, 2024, when the website will be shut down. Not that the site was very good. Their *Prevention of SARS-CoV-2 Infection* page mentions masks once on the whole page and does not mention nasal sprays: > The risk of SARS-CoV-2 transmission can be reduced by covering coughs and sneezes, wearing a well-fitted mask around others, and isolating when experiencing symptoms. Frequent handwashing also effectively reduces the risk of infection. > Vaccination is the most effective way to prevent COVID-19. [Older versions](https://files.covid19treatmentguidelines.nih.gov/guidelines/archive/covid19treatmentguidelines-10-27-2021.pdf) of their PDF mention N95s. The only mention of N95s, other than recommending them for healthcare workers, is to claim that surgical masks are just as good: > There is evidence from studies of viral diseases, including SARS, that both surgical masks and N95 respirators reduce the risk of transmission.6 Moreover, surgical masks are probably not inferior to N95 respirators for preventing the transmission of respiratory viral infections; a recent systematic review and meta-analysis of randomized controlled trials that compared the protective effects of medical masks and N95 respirators demonstrated that the use of medical masks did not increase the incidence of laboratory- confirmed viral respiratory infections (including coronavirus infections) or clinical respiratory illness. (That is incorrect.) The [latest version](https://files.covid19treatmentguidelines.nih.gov/guidelines/covid19treatmentguidelines.pdf) does not mention the existence of N95s or KN95s, it just says "a well-fitted mask". And N95s and KN95s are not mentioned on the site itself, outside of these PDFs.
citationsneeded.libsyn.com
> In this News Brief we are joined by friend of the show, [Maximillian Alvarez](https://therealnews.com/author/maximillian-alvarez) of [The Real News](https://www.youtube.com/user/therealnews), to discuss Democrats' pathetic, myopic, and nihilistic attempt to play the Racist Reverse Uno Card on Congressional Republicans.
I warned you
What I did: Tried embedding the image from [this post](https://toots.matapacos.dog/@theCommunistCenter/111763957593720910) on Hexbear: `` Expected result: Image is embedded Actual result:  More info: These hosts are whitelisted for embedding images on Hexbear: - chapo.chat - discuss.tchncs.de - hexbear.net - i.imgur.com - jlai.lu - lemm.ee - lemmy.ml - lemmy.world - lemmygrad.ml - mander.xyz - pathfinder.social - possumpat.io - test.hexbear.net - toots.matapacos.dog - ttrpg.network - www.hexbear.net But in the case of `toots.matapacos.dog`, `assets.toots.matapacos.dog` should be whitelisted instead.
Interview starts at 4:08:02 in [the VOD](https://www.twitch.tv/videos/2034536667?t=4h8m2s) Context: Media is putting out articles like https://www.vice.com/en_us/article/epv74k/everything-we-know-about-timhouthi-chalamet-the-yemeni-influencer-celebrating-red-sea-ship-raids , so Hasan talked to him directly Important: Hasan asks if he knows what One Piece is https://clips.twitch.tv/ExcitedSparklyRamenWoofer-Kdnimydpec0yxUYR
> Post here if you’re able to help mod, we’d greatly appreciate it. > > Ideally your account should be on lemmy.ml, and also have a history of posting here.
Edit: Convo is over, it started at 1:57:47 in [the VOD](https://www.twitch.tv/videos/2024714439?t=1h57m47s)
absolutelymaybe.plos.org
News from US Project NextGen: > The 3 vaccines from the USA chosen for Project NextGen are: > > * Gritstone Bio’s self-amplifying mRNA vaccine aiming to be “variant-proof”; > * Covi-Vac/CoviLiv: A live virus intranasal vaccine from Codagenix; and > * Castlevax viral vector intranasal vaccine, from a Mount Sinai Hospital spin-off. Mucosal vaccines: > * Mucosal vaccines are currently authorized for use in 6 countries: China, India, Indonesia, Iran, Morocco, and Russia. There are 5 of these vaccines: China has 2, and one of them is authorized in 3 countries: > - Ad5-nCoV (Convidecia Air) Viral vector (adenovirus) vaccine by by CanSino (China) > - BBV154 (iNCOVACC) Viral vector (adenovirus) intranasal vaccine by Bharat Biotech (India), using ChAd-SARS-CoV-2-S by Washington University in St Louis > - DNS1-RBD (Pneucolin) viral vector intranasal vaccine, by Beijing Wantai BioPharm (China) > - Razi Cov Pars Protein subunit by Razi Vaccine & Serum Research Institute (Iran) > * 27 have reached clinical trial, with at least one of those has been discontinued. > * 6 mucosal vaccines have reached phase 3 trials, including the 5 authorized vaccines.
I thought I had the post saved, but I guess not